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Cefotaxim cefalosporin

Cephalosporin - Wikipedi

The cephalosporins resist attack by some β-lactamases, but resistance is mediated by other means. Pharmacokinetics. Usually, cephalosporins are excreted unchanged in the urine, but some, including cefotaxime, form a desacetyl metabolite which possesses some antibacterial activity. Many are actively secreted by the renal tubule, a process which. Since the first cephalosporin was discovered in 1945, scientists have been improving the structure of cephalosporins to make them more effective against a wider range of bacteria. Each time the structure changes, a new generation of cephalosporins are made. Third generation cephalosporins were the third generation of cephalosporins to be develop Merck and the Merck Manuals. Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world Cefotaxime is a third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls Cefotaxime is contraindicated in patients with cephalosporin hypersensitivity or cephamycin hypersensitivity. Cefotaxime should be used cautiously in patients with hypersensitivity to penicillin. The structural similarity between cefotaxime and penicillin means that cross-reactivity can occur

The empirical formula of Cefotaxime (cefotaxime for injection) Sodium is C 16 H 16 N 5 NaO 7 S 2, representing a molecular weight of 477.45.. Cefotaxime (cefotaxime for injection) Sodium contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity Cefotaxime, ceftazidime, ceftriaxone, ceftizoxime, and moxalactam have excellent penetration into the cerebrospinal fluid. Enterobacter species have a tendency to become resistant during cephalosporin therapy, and thus cephalosporins are not the drugs of choice for Enterobacter infections. AntiPseudomonal Cephalosporin Cephalosporin Antibiotics. Cephalosporin antibiotics are used to treat ear infections, lower respiratory infections, upper respiratory infections, urinary tract infections, skin infections, pneumonia, and sinus Infections. They work by slowing the growth of the bacteria that is causing the infection

Third Generation Cephalosporins - GlobalRP

Cefotaxime - Drugs.co

  1. The aim of this work was to review the published data on the pharmacokinetics of cephalosporins in neonates to provide a critical analysis of the literature as a useful tool for physicians. The bibliographic search was performed for articles published up to December 3, 2010, using PubMed. In.
  2. This topic reviews the clinical manifestations, pathogenesis, and diagnosis of hypersensitivity reactions to cephalosporins. Issues of cross reactivity between cephalosporins, penicillins, and related drugs, and the subsequent use of cephalosporins and related antibiotics in patients with cephalosporin or penicillin allergy, are discussed.
  3. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.1M), or click on a page image below to browse page by page
  4. ister; thus, these agents are frequently used beta-lactam drugs. The classification, spectrum of activity, and pharmacology of the cephalosporins will be reviewed here

Cefotaxime - Side Effects, Dosage, Interactions - Drugs

Medscape - Indication-specific dosing for Claforan (cefotaxime), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information Cefotaxime Sodium is the sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall William A. Craig, David R. Andes, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015 Spectrum of Activity. The cephalosporins are active against a wide variety of aerobic and anaerobic bacteria (Tables 21-2 and 21-3). 29-63 Most drugs are active against streptococci and staphylococci The pharmacology of the cephalosporins is similar to that of the penicillins, excretion being principally renal. Cephalosporins penetrate the cerebrospinal fluid poorly unless the meninges are inflamed; cefotaxime and ceftriaxone are suitable cephalosporins for infections of the CNS (e.g meningitis) For confirmation of ESBL production ceftazidime (30ug), ceftazidime + clavulanic acid combination disc (30/10ug) manufactured by HiMedia and cefotaxime (30ug) + cefotaxime clavulanic acid (30/10ug) prepared in laboratory were used

cephalosporins [TUSOM Pharmwiki

The cross-reactivity between cephalosporins and penicillins is an important topic in medicine. In this article an experienced infectious diseases pharmacist discusses the importance of chemical structure side chains in considering when an allergy to a penicillin may translate into an allergy for a cephalosporin and vice versa Cefotaxime is a cephalosporin antibiotic that works by fighting the bacteria in your body. It is used to treat bacterial infections including severe or life-threatening infections. People who have undergone surgery are more prone to get severe infection and cefotaxime is given to them in order to prevent infections Cephalosporin drugs are beta lactam antibiotics that inhibit the cell wall of bacteria. Cephalosporin C was first isolated from a fungus named as Cephalosporium acremonium by Dr. Abraham in 1948. These are bactericidal antibiotics as they kill the micro-organisms when used at therapeutic dose. Mode of Action Cefotaxime injection may also be used before surgery, and during and after a cesarean section, in order to prevent the patient from getting an infection. Cefotaxime injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria

This is because while research shows a low risk of reacting to a cephalosporin in people with a penicillin allergy, there is one exception—first-generation cephalosporins like cephalexin (Keflex) and cefazolin (Ancef) cause higher rates of allergic reactions in people with a penicillin allergy than people without a penicillin allergy 301 Moved Permanently. nginx/1.14.0 (Ubuntu Cephalosporin là kháng sinh diệt khuẩn và có cùng cơ chế hoạt động như các thuốc beta-lactam khác(như penicillin), nhưng ít nhạy cảm với β-lactamases. Cephalosporins ngăn cản sự tổng hợp các lớp peptidoglycan hình thành thành tế bào vi khuẩn. Lớp peptidoglycan rất quan trọng trong cấu. The antibiotic cefotaxime (Claforan) is given either by an injection into a large muscle, usually your hip or buttock, or in an intravenous (IV) infusion through a needle or catheter in one of your veins. The IV infusion takes about 30 minutes to complete

Buy Cefotaxime acid, cephalosporin antibiotic (CAS 63527-52-6), a third-generation cephalosporin antibiotic. Join researchers using high quality Cefotaxime acid, cephalosporin antibiotic from Abca Cephalosporin Clinical Isolate Cefotaxime Transferable Resistance Klebsiella These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves Cefotaxime for Injection, USP, like other cephalosporins, has no activity against Chlamydia trachomatis. Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate anti‑chlamydial coverage should be added บทนำ . กลุ่มยาเซฟาโลสปอริน (Cephalosporin) เป็นยาปฏิชีวนะประเภท เบต้า-แลคแตม (B-Lactam antibiotic) โดยมีแหล่งกำเนิดมาจากเชื้อราที่รู้จักกันในชื่อว่า Cephalosporium โดยยา เซฟ. Also known as Cefotaxim, Cefotaxima, Cefotaximum, Cephotaxime, Céfotaxime. A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of.

Video: Third Generation Broad-Spectrum Cephalosporin

Class of Antibiotic > cephalosporin - inhibits the mucopeptide synthesis in bacterial cell walls.. Dose: 1-3 grams IV every 8 hours. Diluted in 50-100ml of Normal Saline but typically is put in 20ml Syringes because it can be given IV push over 5-10 minutes Cephalosporins are one of the most widely prescribed antimicrobial drugs. They can be classified into 5 to generations and the medical students often have hard time remembering the names of drugs falling into different generations as the names appear and sound similar THIRD GENERATION CEPHALOSPORINS Prototype of third generationcephalosporin. potent action on aerobic gramnegative bacteria. Used against meningitis causedby gram negativebacilli,septicaemias,hospitalacquired infections. Attains high CSF levels. plasma T1/2-1hr. DOSE:1-2gm i.m or i.v. 8-12 hrly.CEFOTAXIME 16

Emergency treatment of suspected bacterial meningitis or meningococcal disease, before urgent transfer to hospital, in patients who cannot be given benzylpenicillin (e.g. because of an allergy peritoneal fluids, and in urine, excellent drug levels are achieved. The cephalosporins are also found in the bile. Cefotaxime, ceftriaxone, ceftazidime enter CSF in concentrations adequate to treat meningitis. C. Metabolism Cefotaxime is metabolized to desacetyl derivative, but this derivative has antibacterial activity and has longer half-life

Cephalosporins - National Institutes of Healt

Second generation cephalosporins include cefaclor, cefuroxime and cefoxitin. They are more stable to hydrolysis by beta-lactamases produced by Gram-negative bacteria and therefore have enhanced activity against many of the Enterobacteriaceae, e.g. Escherichia coli, Salmonella. 2; Ceftriaxone is a third generation cephalosporin The parenterally administered cephalosporins are widely used as broad spectrum antibiotics for moderate-to-severe infections with susceptible organisms. Despite their widescale use, cases of drug induced liver disease from the cephalosporins are very rare, with only isolated case reports having been published. Backgroun Multiply-resistant coliforms are associated with high-level usage of cephalosporins, particularly cefotaxime, ceftriaxone and ceftazidime. 5 - 9, 44, 87, 93 - 97 These antibiotics induce and select for ESBL coliforms (ESBLC). 87, 95, 98 If cephalosporins are avoided, there is less chance of selecting these highly resistant bacteria, and. Buy Cefotaxime sodium, cephalosporin antibiotic (CAS 64485-93-4), a water soluble third-generation cephalosporin antibiotic. Join researchers using high quality Cefotaxime sodium, cephalospori

The other clinically useful grouping is the original third generation cephalosporins. Cefotaxime and ceftriaxone, while having different pharmacokinetics, can be used interchangeably for the majority of indications and decisions about which one is available in a Canadian institution are made predominantly on economic grounds Cephalosporins are categorized by generation, a classification that relates to their antimicrobial properties. There are four generations; each newer generation of cephalosporins having greater gram-negative antimicrobial effectiveness than the generation before. The later the generation, the greater the cephalosporin's effectiveness. There is also the possibility that tests for infant infection can be altered if mom is taking cephalosporins and breastfeeding. The American Academy of Pediatrics lists some cephalosporins as safe for use during breastfeeding, but it is best to check for information specific to the drug you are prescribed Cefotaxime sodium is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefotaxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Mechanism of Resistanc

Cephalosporin - an overview ScienceDirect Topic

Study 34 Cephalosporins flashcards from Alec V. on StudyBlue. Hospital acquired infections d/t BL+ orgs resistant to 3rd gen CEPHS such as Pneu, bacter, UTI and meningitis but includes pseudomona cephalosporins.{R-80} Use of these antimicrobials is generally reserved for infections that are resistant to first-generation cephalosporins. Third-generation cephalosporins include cefixime, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, ceftizoxime, and ceftriaxone. Third-generation cephalosporins are the most effective of th The difficulty in answering your question is the meaning of safe and the meaning of penicillin allergic patient. The medical literature suggests there is greater risk in giving cephalosporin, particularly first generation cephalosporin, to a patient with a history of penicillin allergy than to a patient without penicillin allergy (2-4 fold increased risk)

Cefotaxime sodium is a third generation cephalosporin antibiotic. TOKU-E offers two forms of cefotaxime: cefotaxime sodium, USP (C011) and cefotaxime sodium, CulturePure® (C106). Both forms have are freely soluble in aqueous solution (50 mg/mL) Cefotaxime is a broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic. Cefotaxime is exceptionally active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins. It is similar to other cephalosporins in activity against gram-positive bacteria Medical definition of cefotaxime: a semisynthetic cephalosporin antibiotic that is administered parenterally in the form of its sodium salt C16H16N5NaO7S2 Cefotaxim DEKLARATION Cefotaxim (J01DA10) är ett cefalosporin för parenteralt bruk med brett antibakteriellt spektrum och höggradig stabilitet mot många betalaktamaser, men som regel inte ESBL A, ESBL M eller ESBL CARBA. RAFs BEDÖMNING Cefotaxim har god aktivitet mot flertalet grampositiva och aeroba gramnegativa bakterier

Cefotaxime is a cephalosporin antibiotic that inhibits cell wall synthesis and is efficient against gram-negative bacteria Cephalosporins function as cell wall inhibitors (same as penicillin). In general, there are 4 generations with each generation having increasing Gram-ve cover and lesser Gram+ve cover. The cephalosporins used to treat meningitis are cefotaxime and ceftriaxone. The cephalosporins used to treat pseudomonas are ceftazadime, cefoperazone and cefepime Background Penicillin-resistant strains of Streptococcus pneumoniae are now found worldwide, and strains with resistance to cephalosporin are being reported. The appropriate antibiotic therapy for. Cephalosporins have cross allergenicity with penicillins. There is a 10% chance that if a patient is allergic to penicillin, that they will be allergic to cephalosporins. If they have had a history of anaphylactic shock with penicillin, we won't risk it. If it was just something like a rash, we could take the risk if it's appropriate Evaluation of the use of cephalosporin antibiotics in pediatrics Bushra Riaz* and Humera Khatoon Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Karachi-74600, Pakistan

Cefotaxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Cefotaxime is used to treat many kinds of bacterial infections, including severe or life-threatening forms Summary. Synopsis: Cefotaxime 1 is a new 'third generation' semisynthetic cephalosporin administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the 'first' and 'second generation' cephalosporins

The aim of this study was to compare the frequency of occurrence of digestive carrying of 3rd generation cephalosporin-resistant enterobacteriaceae (EB C3G-R), acquired during hospitalization in one of the participating departments, between patients treated with ceftriaxone and patients treated with cefotaxim also occur. Concomitant administration of aminoglycosides and cephalosporins has caused nephrotoxicity. Individuals who are sensitive to beta lactam antibiotics, both penicillins and cephalosporins, may experience contact or systemic hypersensitivity and anaphylaxis upon exposure to this drug. EU Indication of danger: Harmful Irritant EU Hazard. Therapeutic Class Review Third Generation Cephalosporins Therapeutic Class • Overview/Summary: The cephalosporin family of antibiotics is part of a larger group known as β-lactam antibiotics. Agents within this group share the structural feature of a β-lactam ring. The β If C. trachomatis is a suspected pathogen, appropriate anti-chlamydial coverage should be added, because cefotaxime sodium has no activity against this organism.. To prevent postoperative infection in contaminated or potentially contaminated surgery, the recommended dose is a single 1 gram IM or IV administered 30 to 90 minutes prior to start of surgery The brand name for the prescription antibiotic cefotaxime is Claforan. This medication is used to treat certain types of bacterial infections. If you have questions about taking cefotaxime or possible side effects, talk with your doctor or pharmacist

List of Third Generation Cephalosporins - Drugs

  1. ocephalosporanic acid (7-ACA) core, which then could be synthetically substituted with other sidechains
  2. Cephalosporin: structure, classification, clinical use and mode of action structure of cephalosporin Cephalosporin is a β-lactam antibiotic that inhibits bacterial cell wall synthesis
  3. bacteria resistant to the third-generation cephalosporin cefotaxime. Fecal samples were collected from the recto anal junction of cattle at the age of ∼3, 6, 9, and 12 months and tested for cefotaxime resistant bacteria (CRB) and the presence of extended spectrum β-lactamases (ESBLs). The colonization dynamics of CRB in calves (n = 188) wa
  4. Cefotaxime is a type of antibiotic called a cephalosporin. These antibiotics are related to penicillin. Cefotaxime is used to treat infections caused by bacteria
  5. Cefotaxime : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names Cefotaxime is the prototype of the third generation cephalosporins. It is deacetylated in the body; the metabolite exerts weaker but synergistic action with the parent drug
  6. Cephalosporins exert bactericidal activity by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis. Pharmacodynamic

Cephalosporins - Infectious Diseases - Merck Manuals

Compare prices and print coupons for Cefotaxime (Generic Claforan) and other Skin Infection, Urinary Tract Infection, Bacterial Infection, Lower Respiratory Infection, and Meningitis drugs at CVS, Walgreens, and other pharmacies cephalosporins and 1.1% for third-generation cephalosporins, possibly due to the involvement of similar side chains. Patch tests are a useful diagnostic tool to assess cross-reactivity, but a graded challenge is mandatory because a negative patch test does not always mean tolerability. Key words: Cell-mediated hypersensitivity. Cephalosporins

Cephalosporins are derived from cephalosporin C which is an acid-stable molecule. FIRST GENERATION. Are moderate spectrum agents. Effective for treating staphylococcal and streptococcal infections and for skin and soft-tissue infections, as well as for streptococcal pharyngitis A process for the preparation of the cephalosporanic antibiotics CEFOTAXIME and CEFTRIAXONE. Said process consists in reacting 7-aminocephalosporanic acid (7-ACA) or 7-amino-3[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl]-3-cephem-4-carboxylic acid (7-ACT) with suitably activated 4-chloro-2-methoxyimino-3-oxobutyric acid, and subsequently cyclizing the intermediate chloromethoxyimino.

Cefotaxime is a cephalosporin antibiotic. Cephalosporins are part of a larger group of medications known as beta-lactam antibiotics, named after the ring-like lactam structure of these drugs. Cefotaxime works by stopping bacteria from making cell walls, which eventually causes the bacteria to die. Cephalosporins are related to penicillin In addition to the adverse reactions listed above which have been observed in patients treated with cefotaxime sodium, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics: allergic reactions, hepatic dysfunction including cholestasis, aplastic anemia, hemorrhage, and false-positive. Cephalosporin Markets in China - China' s demand for Cephalosporins has grown at a fast pace in the past decade. In the next five years, both production and demand will continue to grow How to use Cefotaxime Solution, Reconstituted (Recon Soln) This medication is given by injection into a muscle or vein as directed by your doctor. If given by injection into a vein, inject the. Nhiều cephalosporin như cefuroxim, moxalactam, cefotaxim, ceftriaxon, cefepim, ceftizoxim thấm được vào dịch não - tủy với nồng độ đủ để điều trị viêm màng não. Cephalosporin cũng qua được nhau thai, và đạt nồng độ cao trong hoạt dịch và dịch màng ngoài tim

Cefotaxime C16H17N5O7S2 - PubChe

  1. Generally, the 'second generation cephalosporins' exhibit the same spectrum of antibacterial activity as that of the first generation cephalosporins.The glaring exceptions being that these are comparatively much more active against certain specific organisms, namely: Haemophilus influenzae, gonococcus, and some enteric Gram-negative bacilli
  2. History of hypersensitivity to cephalosporins or major allergic response to a penicillin. Precautions. Renal impairment: cefotaxime has a high renal clearance, therefore reduce dose in moderate to severe renal impairment
  3. #### Key points Many patients claim to be allergic to penicillin. For those confirmed as being truly allergic (type 1 allergy, with features of urticaria, pruritic rash, etc), the cited overall rate of 10% cross reactivity between penicillin and cephalosporins is an overestimate.1 For life threatening infections such as bacterial meningitis, septicaemia, and severe respiratory tract infections.
  4. Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes. General descriptio

Cefotaxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Cefotaxime is used to treat many kinds of bacterial infections, including severe or life-threatening forms. Cefotaxime is also used to prevent infections in people having surgery. Cefotaxime may. Mumbai, April 16: Lupin Limited has recently filed 2 ANDAs -- Abbreviated New Drug Applications - with the USFDA for Ceftriaxone injection and Cefotaxime injection in the cephalosporins segment. The filings mark the company's entry into this segment in the US generics markets & the first step towards capturing a share of the market for niche. How to use Cefotaxime SODIUM Vial. This medication is given by injection into a muscle or vein as directed by your doctor. If given by injection into a vein, inject the drug slowly over at least 3. ยากลุ่ม Cephalosporins จัดเป็นยาปฏิชีวนะกลุ่ม B-lactams ที่สกัดจากเชื้อรา Cephalosporium acremonium ซึ่งสารประกอบที่สกัดได้จากเชื้อรานี้มี 3 ชนิด คือ Cephalosporin P, Cephalosporin N และ Cephalosporin C.

Claforan (cefotaxime) dose, indications, adverse effects

Thuốc Cefotaxime, Thuốc Cefotaxim, Cefotaxime là gì, Công dụng , Chỉ định , Liều dùng , Cách dùng thuốc Cefotaxime, Chống chỉ định, tác dụng phụ Cefotaxime, Dược lực Cefotaxime - Thuocbietduoc.com.v As with cefotaxime plus gentamicin (Refobacin et al). Alternatives are carbapenems like imipenem (ZIENAM et al) and meropenem (MERONEM) and ciprofloxacin. The treatment of endocarditis should be done with a cephalosporin of group 3 or a carbapenem in high doses in combination with an aminoglycoside

Cefotaxime (Cefotaxime for Injection): Side Effects

Cephalosporins John A. Bosso, Pharm.D. PHMPR732.cepha.bosso.rev7.05 PHMPR-732 J.Bosso MedicalUniversityofSouthCarolina Generalizations Spectrum - most Gram-positive. THE USE OF CEFOTAXIME IN SERIOUS AND PROBLEM SURGICAL INFECTIONS M.BALASEGARAM M.R.DEVANAND BALWANT SINGH SUMMARY Cefotaxime [HR 756], a third generation cephalosporin with pronounced antibacterial acti­ vity against the Enterobacteriaceae, was assessed in serious and problem antibiotic resistant infec­ tion. Good clinical success was. Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram (+) and Gram (-) bacteria. Indications. For treatment of infections due to Cefotaxim susceptible bacteria: • osteomyelitis; • septicaemi

Cephalosporin Antibiotics: Generations, Uses, Side Effect

Define cefotaxime. cefotaxime synonyms, cefotaxime pronunciation, cefotaxime translation, English dictionary definition of cefotaxime. n. A broad-spectrum cephalosporin antibiotic, C16H17N5O7S2, given intravenously in the form of its sodium salt. Noun 1. cefotaxime - a parenteral.. Study Cephalosporins Flashcards at ProProfs - Cephalosporins. 1. Related to route of administration (GI upset for oral, injection site pain for IM, phlebitis for IV)2.Kidney damage at high doses for patients with pre-existing renal disease, or if given in conjunction with other nephrotoxic drug Several advanced generation cephalosporins have shown equal efficacy in clinical trials, but only cefotaxime, ceftriaxone and ceftazidime are currently approved for the treatment of patients with.

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